期刊
MOLECULES
卷 24, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules24030396
关键词
G-quadruplex; G-quadruplex ligand; G-quadruplex-related proteins; helicase; anti-tumor
资金
- National Natural Science Foundation of China [81673286]
- Guangdong Provincial Science and Technology Development Special Foundation (Public Interest Research and Capacity Building) [2016A020217006]
G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G-quadruplexes has become a novel promising anti-tumor strategy. Different kinds of small molecules targeting the G-quadruplexes have been designed, synthesized, and identified as potential anti-tumor agents, including molecules directly bind to the G-quadruplex and molecules interfering with the binding between the G-quadruplex structures and related binding proteins. This review will explore the feasibility of G-quadruplex ligands acting as anti-tumor drugs, from basis to application. Meanwhile, since helicase is the most well-defined G-quadruplex-related protein, the most extensive research on the relationship between helicase and G-quadruplexes, and its meaning in drug design, is emphasized.
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