期刊
BIOLOGICAL PSYCHIATRY
卷 78, 期 9, 页码 598-605出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2015.05.010
关键词
Depression; Early life stress; Emotional neglect; fMRI; Longitudinal; Neurodevelopment
资金
- National Institute on Alcohol Abuse and Alcoholism [R01AA016274]
- Genetic and Environmental Risk endowment from the Dielmann Family (DEW)
- National Institute on Drug Abuse [R01DA033369, R01DA031579]
- National Institute of Mental Health [MH087493]
- National Institute on Drug Abuse through the Center for the Study of Adolescent Risk and Resilience [P30DA023026]
- National Institute of Child Health and Human Development through the Center for Developmental Science, University of North Carolina at Chapel Hill [T32HD0737625]
BACKGROUND: Emotional neglect is associated with multiple negative outcomes, particularly increased risk for depression. Motivated by increasing evidence of reward-related ventral striatum (VS) dysfunction in depression, we investigated the role of developmental changes in VS activity on the emergence of depressive symptomatology as a function of emotional neglect. METHODS: We examined relationships between longitudinal neuroimaging of reward-related VS activity, assessments of mood, and measures of emotional neglect in 106 participants first scanned between ages 11 to 15 and then 2 years later. RESULTS: We found that greater levels of emotional neglect were associated with blunted development of reward-related VS activity between the first and second assessments (as indexed by lower residualized change scores). Additionally, we found that decreases in this reward-related VS activity were related to greater depressive symptomatology and partially mediated the association between emotional neglect and subsequent depressive symptomatology. CONCLUSIONS: Our results provide an important demonstration that blunted development of reward-related VS activity as a function of emotional neglect predicts the emergence of depressive symptoms in adolescents. Further, our results are consistent with emerging evidence for the importance of reward-related VS dysfunction in the etiology and pathophysiology of depression. These results are a first step toward developing the ability to predict, prevent, and treat stress-related psychopathology through the targeting of specific neural phenotypes.
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