期刊
MOLECULAR CELL
卷 73, 期 3, 页码 398-411出版社
CELL PRESS
DOI: 10.1016/j.molcel.2019.01.024
关键词
-
资金
- Fellow Award from the Leukemia and Lymphoma Society [5455-17]
- Stanford Graduate Fellowship
- NCI PHS grant [CA09302]
- NIH [GM119334]
- V Foundation Grant [D2018-017]
During transcription, the nascent RNA strand can base pair with its template DNA, displacing the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are common across many domains of life and cause DNA damage in certain contexts. In this review, we summarize recent results implicating R-loops as important regulators of cellular processes such as transcription termination, gene regulation, and DNA repair. We also highlight recent work suggesting that R-loops can be problematic to cells as blocks to efficient transcription and replication that trigger the DNA damage response. Finally, we discuss how R-loops may contribute to cancer, neurodegeneration, and inflammatory diseases and compare the available next-generation sequencing-based approaches to map R-loops genome wide.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据