期刊
MOLECULAR CANCER
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12943-019-0984-4
关键词
Exosomes; Cancer; Noncoding RNAs; Function
资金
- National Key Research and Development Program
- National Natural Science Foundations of China [2017YFC1200204, 31670171, 81728011]
Extracellular vesicles (EVs) membranes enclose nanosized vesicles with a size range of 30-150nm and are plentiful in our body in both physiological and pathological conditions. Exosomes, a type of EV, are important mediators of intracellular communication among tumor cells, immune cells, and stromal cells. They can shuttle bioactive molecules, such as proteins, lipids, RNA, and DNA; however, the precise function of EVs remains largely unknown. In recent years, tumor-associated cargo in exosomes has been a hot topic in research, especially with respect to noncoding RNAs (ncRNAs). Herein, we review the role of exosomal ncRNAs, including miRNAs and long noncoding RNAs, in tumor biological processes. Clinically, exosomal ncRNAs may eventually become novel biomarkers and therapeutic targets in cancer progression.
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