期刊
MOLECULAR CANCER
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12943-019-0995-1
关键词
Exosomes; Pre-metastatic niche; Tumor microenvironment; Immunoregulation; Biomarker
资金
- National Natural Science Foundation of China [81560385, 81671542]
- Medical Scientific and Technological Research Project of Henan Province [201702027]
- Youth Innovation Fund Project of The First Affiliated Hospital of Zhengzhou University [YNQN2017035]
- China Postdoctoral Science Foundation [2017 M610462]
- National Natural Science Foundation of Henan Province [182300410342]
- Health Commission Technology Talents Overseas Training Project of Henan Province [2018140]
A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes play an irreplaceable role in the development of pre-metastatic niches, and mainly function as communication medium. In this review, we analyzed the effects of exosomes on pre-metastatic niches from various perspectives, including inflammation, immune response, angiogenesis, organotropism, matrix remodeling and biomarker expression. In particular, exosomes express programmed death ligand 1 (PD-L1) and cause the immune escape of tumor cells. The immunomodulatory effects of exosomes and their potential in liquid diagnosis have drawn our attention. The potential value of exosomes and pre-metastatic niches will be realized in the field of immunity therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据