期刊
MOLECULAR CANCER
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12943-019-1001-7
关键词
Exosomes; Gastric cancer; Progression; Biomarker; Target
资金
- National Natural Science Foundation of China [81672416, 81572075]
- Jiangsu Province's Major Project in Research and Development [BE2015667]
- Major Natural Science Reasearch Project for Universities in Jiangsu Province [18KJA320001]
Exosomes are nanosized extracellular vesicles that can be released by almost all types of cells. Initially considered as the garbage bins acting to discard unwanted products of cells, exosomes are now recognized as an important way for cellular communication by transmitting bioactive molecules including proteins, DNA, mRNAs, and non-coding RNAs. The recent studies have shown that exosomes are critically involved in human health and diseases including cancer. Exosomes have been suggested to participate in the promotion of tumorigenesis, tumor growth and metastasis, tumor angiogenesis, tumor immune escape, and tumor therapy resistance. Increasing evidence indicate that exosomes play important roles in gastric cancer development and progression. In this review, we summarized the current understanding of exosomes in gastric cancer with an emphasis on the biological roles of exosomes in gastric cancer and their potential as biomarkers for gastric cancer diagnosis as well as potential targets for gastric cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据