期刊
MOLECULAR BIOLOGY REPORTS
卷 46, 期 2, 页码 1775-1786出版社
SPRINGER
DOI: 10.1007/s11033-019-04628-7
关键词
Blue-green algae; Aphanizomenon flos-aquae; Fermentation; Antioxidant; Anti-glycation; RAW264; 7 cells
资金
- Japan Health & Research Institute, Tokyo, Japan
- Suzuki Nori Co., Choshi, Japan
- Dr's Choice, Tokyo, Japan
To clarify the antioxidant, anti-glycation and immunomodulatory capacities of fermented blue-green algae Aphanizomenon flos-aquae (AFA), hot aqueous extract suspensions made from 10% AFA were fermented by Lactobacillus plantarum AN7 and Lactococcus lactis subsp. lactis Kushiro-L2 strains isolated from a coastal region of Japan. The DPPH and O-2(-) radical scavenging capacities and Fe-reducing power were increased in the fermented AFA. The increased DPPH radical scavenging capacity of the fermented AFA was fractionated to mainly<3kDa and 30-100kDa. The increased O-2(-) radical scavenging capacities were fractionated to mainly<3kDa. Anti-glycation activity in BSA-fructose model rather than BSA-methylglyoxal model was increased by the fermentation. The increased anti-glycation activity was fractionated to mainly 30-100kDa. The NO concentration in the murine macrophage RAW264.7 culture media was high with the fermented AFA. The increased immunomodulation capacity was also fractionated to mainly 30-100kDa. These results suggest that the fermented AFA is a more useful material for health foods and supplements.
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