期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 481, 期 -, 页码 62-70出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2018.11.010
关键词
Hydrogen peroxide; Thyroid; DNA damage; Antioxidant enzymes
资金
- Fonds Erasme pour la Recherche Medicale
- FRS-FNRS: Fonds de la Recherche Scientifique Medicale
- Belgian Kids' Fund
- Association Vincotte Nuclear (AVN)
- Fonds Docteur J.P Naets
We studied the mechanism that may explain the relative resistance of thyrocytes to H2O2 compared to other cell types. Ability to degrade H2O2, glutathione peroxidase (GPx) activity, heme oxygenase-1 (HO-1) expression, cell survival and capacity to repair DNA damage after H2O2 exposure or irradiation were measured in human thyrocytes in primary culture and compared to the values obtained in human T-cells and different cell lines. Compared to other cell types, thyrocytes presented a low mortality rate after H2O2 exposure, rapidly degraded extracellular H2O2 and presented a high basal seleno-dependent GPx activity. Only in thyrocytes, H2O2 upregulated GPx activity and expression of HO-1 mRNA. These effects were not reproduced by irradiation. DNA damage caused by H2O2 was more slowly repaired than that caused by irradiation and not repaired at all in T-cells. Our study demonstrates that the thyrocyte has specific protective mechanisms against H(2)O(2 )and its mutagenic effects.
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