期刊
MITOCHONDRION
卷 48, 期 -, 页码 16-30出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2019.02.002
关键词
Mitochondria; Cell-free-circulating mtDNA; Transplant; Regeneration; Inflammation; Therapy; Biomarker
资金
- Universidad San Francisco de Quito (USFQ) [5501]
Mitochondria play an important role as an intracellular energy plant and signaling organelle. However, mitochondria also exist outside cells where they could mediate cell-to-cell communication, repair and serve as an activator of the immune response. Their effects depend on the mitochondrial state or the form in which it is present, either as a whole functional structure as fragments or only as mitochondrial DNA. Herein, we provide evidence of why extracellular mitochondria and their varying forms are considered regenerative factors or pro inflammatory activators. Understanding these aspects will provide the base of their use in therapy or as a biomarker of disease severity and prognosis.
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