期刊
MICROBIAL DRUG RESISTANCE
卷 25, 期 3, 页码 317-325出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2018.0418
关键词
Stenotrophomonas; colistin; meropenem; antibiotic resistance; gene transfer
资金
- National Natural Science Foundation of China [31800118, 31500094]
- China Postdoctoral Science Foundation [2017M621965]
- Innovation Project of Shandong Academy of Medical Sciences
Development of antibiotic resistance can be achieved either by mutation or by acquiring a resistance gene from foreign sources, with some resistance genes likely originating in microbial populations to counteract antibiotics present in natural ecosystems. In this study, we describe the first report of a strain of nonclinical multidrug-resistant Stenotrophomonas sp. strain G4 with high-level resistance to colistin and meropenem, phylogenetically distinct from well-studied multiple drug-resistant species of Stenotrophomonas maltophilia. As the high-level colistin resistance of this strain was of great concern, the genome of this strain was completely sequenced. Only one chromosome was identified, and no plasmids were found. Chromosomal gene variants and other potential genetic determinants conferring resistance to colistin and meropenem were comparatively analyzed, and results showed that strain G4 harbored two putative colistin resistance determinants (named mcr-5.3 and mcr-8.2) and four extended-spectrum beta-lactamase genes. In addition, 12 genes potentially encoding seven different types of efflux pumps were identified, which may have a major role in acquisition/transfer of colistin resistance. Our discovery of multiple antibiotic resistance determinants in this environmental strain extensively expands our understanding of the extent of dissemination of colistin and meropenem resistance.
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