期刊
MICROBIAL CELL FACTORIES
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12934-019-1096-y
关键词
Metabolic engineering; Nutraceuticals; Value-added products; Co-culture system
资金
- Camille and Henry Dreyfus Foundation
- Air Force Office of Scientific Research [FA9550-14-1-0089]
- Office of Naval Research (ONR) [N00014-15-1-2785]
Metabolic engineering allows for the rewiring of basic metabolism to overproduce both native and non-native metabolites. Among these biomolecules, nutraceuticals have received considerable interest due to their health-promoting or disease-preventing properties. Likewise, microbial engineering efforts to produce these value-added nutraceuticals overcome traditional limitations of low yield from extractions and complex chemical syntheses. This review covers current strategies of metabolic engineering employed for the production of a few key nutraceuticals with selecting polyunsaturated fatty acids, polyphenolic compounds, carotenoids and non-proteinogenic amino acids as exemplary molecules. We focus on the use of both mono-culture and co-culture strategies to produce these molecules of interest. In each of these cases, metabolic engineering efforts are enabling rapid production of these molecules.
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