期刊
MICROBES AND INFECTION
卷 21, 期 7, 页码 296-304出版社
ELSEVIER
DOI: 10.1016/j.micinf.2019.01.005
关键词
Esophageal squamous cell carcinoma; Porphyromonas gingivalis; NF-kappa B; Proliferation; Metastasis
资金
- Scientific Research Project of Guangzhou City [201804010458]
- Science and Technology Foundation of Jiangxi Provincial Department of Education [GJJ170858]
Esophageal carcinoma, with a increasing incidence, is one of the most aggressive carcinomas in gastrointestinal tract. Epidemiologic studies demonstrate an association of oral pathogens with multiple diseases, including rheumatoid arthritis, cardiovascular diseases, diabetes, and gastrointestinal malignancies. Nevertheless, a causal relationship between oral pathogens and esophageal squamous cell carcinoma (ESCC) has not been elucidated. Here, we found that Porphyromonas was significantly enriched in the saliva of patients with ESCC, compared with that in normal human. In vitro studies showed that Porphyromonas gingivalis (P. gingivalis) promoted the proliferation and motility of ESCC cells, as evidenced by up regulated expression of key molecules implicated in NF-kappa B signaling pathway. These findings, for the first time, demonstrated a role of oral pathogens in inducing ESCC tumorigenesis and metastasis, which might involve regulation of NF-kappa B signaling pathway. (C) 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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