期刊
METABOLOMICS
卷 15, 期 2, 页码 -出版社
SPRINGER
DOI: 10.1007/s11306-019-1484-7
关键词
Metabolic syndrome; Metabolomics; Lipidomics; Epidemiology
资金
- Innovation Oriented research Program on Genomics (SenterNovem) [IGE01014, IGE5007]
- Centre for Medical Systems Biology (CMSB)
- Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NOW) [05040202, 050-060-810]
- Unilever PLC
- EU [FP6 036894]
- European Union's Seventh Framework Programme (FP7/2007-2011) [259679]
- EFSD Albert Renold Travel Fellowship Programme
- European Commission [Health-2013-INNOVATION-1-602757]
BackgroundWe aimed to identify novel metabolite and lipid signatures connected with the metabolic syndrome in a Dutch middle-aged population.Methods115 individuals with a metabolic syndrome score ranging from 0 to 5 [50 cases of the metabolic syndrome (score3) and 65 controls] were enrolled from the Leiden Longevity Study, and LC/GC-MS metabolomics and lipidomics profiling were performed on fasting plasma samples. Data were analysed with principal component analysis and orthogonal projections to latent structures (OPLS) to study metabolite/lipid signatures associated with the metabolic syndrome. In addition, univariate analyses were done with linear regression, adjusted for age and sex, for the study of individual metabolites/lipids in relation to the metabolic syndrome.ResultsData was available on 103 metabolites and 223 lipids. In the OPLS model with metabolic syndrome score (Y-variable), 9 metabolites were negatively correlated and 26 metabolites (mostly acylcarnitines, amino acids and keto acids) were positively correlated with the metabolic syndrome score. In addition, a total of 100 lipids (mainly triacylglycerides) were positively correlated and 10 lipids from different lipid classes were negatively correlated with the metabolic syndrome score. In the univariate analyses, the metabolic syndrome (score) was associated with multiple individual metabolites (e.g., valeryl carnitine, pyruvic acid, lactic acid, alanine) and lipids [e.g., diglyceride(34:1), diglyceride(36:2)].ConclusionIn this first study on metabolomics/lipidomics of the metabolic syndrome, we identified multiple novel metabolite and lipid signatures, from different chemical classes, that were connected to the metabolic syndrome and are of interest to cardiometabolic disease biology.
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