期刊
METABOLIC ENGINEERING
卷 52, 期 -, 页码 190-214出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2018.11.013
关键词
Metabolic pathway engineering; Non-coding RNA; Small regulatory RNA; Antisense RNA; sRNA regulatory network; High-throughput RNA-seq
资金
- NSF [MCB-1716777, DGE-1610403]
- Welch Foundation [F-1756]
Non-coding RNAs (ncRNAs) are versatile and powerful controllers of gene expression that have been increasingly linked to cellular metabolism and phenotype. In bacteria, identified and characterized ncRNAs range from trans-acting, multi-target small non-coding RNAs to dynamic, cis-encoded regulatory untranslated regions and riboswitches. These native regulators have inspired the design and construction of many synthetic RNA devices. In this work, we review the design, characterization, and impact of ncRNAs in engineering both native and exogenous metabolic pathways in bacteria. We also consider the opportunities afforded by recent high-throughput approaches for characterizing sRNA regulators and their corresponding networks to showcase their potential applications and impact in engineering bacterial metabolism.
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