期刊
MEDICINE
卷 98, 期 9, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000014552
关键词
hepatocellular carcinoma; pancreatic progenitor cell differentiation and proliferation factor; prognosis
资金
- National Natural Science foundation of China [81502372]
- Natural Science Foundation of Jiangsu Province (Youth Fund) [BK20130475]
- Jiangsu Provincial Medical Youth Talent [QNRC2016838, QNRC2016839]
- Zhenjiang Science and Technology Pillar Program [SH2014035]
- Foundation for Young Scientists of affiliated Hospital of Jiangsu University [JDFYRC2013009, JDFYRC2016002]
The aim of this study is to investigate the expression of pancreatic progenitor cell differentiation and proliferation factor (PPDPF) and its relationship with clinicopathological factors in hepatocellular carcinoma (HCC). A total of 135 patients diagnosed with HCC who underwent curative surgery were enrolled in this study. The expression of PPDPF was examined by real time-polymerase chain reaction (RT-PCR), western blot, and immunohistochemistry. The prognostic value for each sample was explored. Both RT-PCR and western blot revealed PPDPF expression was upregulated in HCC. Higher PPDPF expression was also observed in HCC (54.07%) detected by immunohistochemistry (IHC), which was significantly associated with tumors size (P = .003), Edmondson-Steiner Grading (P = .021), recurrence (P = .010), and Diolame complete (P = .023). Patients with higher PPDPF expression had increased cancer progression and poorer prognosis than those with lower expression (P = .043). Multivariate analysis indicated PPDPF as an independent prognostic factor (P = .014). Aberrance PPDPF expression might be a useful predictor and could serve as a potential therapeutic target for HCC.
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