期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 96, 期 -, 页码 138-145出版社
ELSEVIER
DOI: 10.1016/j.msec.2018.10.093
关键词
Chemo-photothermal therapy; Reduced graphene oxide; Mesoporous silica; Polydopamine
资金
- Natural Science Foundation of Fujian Province [2015J05172]
- National Natural Science Foundation of China [61605209]
- Science and Technology Service Network Initiative Foundation of CAS [2016T3009]
- Pilot Project of Fujian Province of China [2017Y0084]
- Self-created Area Project of Major Science Technology Innovation Platform of Xiamen [3502ZCQ20171002]
- Project of Collaborative Innovation of Industry-University-Research Institute and Science and Technology Cooperation of Xiamen [3502Z20182021]
The nanoplatform of synergistic chemo-photothermal therapy has superior advantages on antitumor. It is urgently needed to explore novel nanocarrier for improving photothermal performance in drug delivery process. Herein, we synthesized polydopamine doped mesoporous silica-coated reduced graphene oxide (rGO/MSN/PDA) by simply adding dopamine hydrochloride into the oil-water biphasic reaction system as a multifunctional drug carrier for anticancer treatment, which combines chemotherapy and photothermal therapy. The rGO/MSN/PDA showed nearly twice the photothermal conversion efficiency of mesoporous silica-coated graphene oxide (GO/MSN) due to the reduction of GO and doping with PDA. In addition, the rGO/MSN/PDA showed pH response DOX release abilities, which means higher release of DOX in tumor cells. The cell experiments in vitro proved that rGO/MSN/PDA with better biocompatibility compare to GO/MSN might offer a promising tool for improving the therapeutic effects of hepatocellular carcinoma cells through synergistic chemo-photothermal therapy.
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