期刊
BIOLOGICAL PSYCHIATRY
卷 77, 期 12, 页码 1079-1088出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2015.03.013
关键词
Discoordination; Excitation-inhibition coupling; Neural coordination; Neural ensemble; Neural synchrony; Oscillations
资金
- National Institutes of Health [R01MH084038, R01MH099128, R01AG043688]
Animal models of mental illness provide a foundation for evaluating hypotheses for the mechanistic causes of mental illness. Neurophysiological investigations of neural network activity in rodent models of mental dysfunction are reviewed from the conceptual framework of the discoordination hypothesis, which asserts that failures of neural coordination cause cognitive deficits in the judicious processing and use of information. Abnormal dynamic coordination of excitatory and inhibitory neural discharge in pharmacologic and genetic rodent models supports the discoordination hypothesis. These observations suggest excitation-inhibition discoordination and aberrant neural circuit dynamics as causes of cognitive impairment, as well as therapeutic targets for cognition-promoting treatments.
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