期刊
MARINE DRUGS
卷 17, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/md17030170
关键词
marine-derived; polysaccharide; anticoagulant; antithrombotic; antiplatelet; glycosaminoglycans; sulfated fucans; sulfated galactans
资金
- COMPETE 2020 through the ERDF
- Portugal 2020 through the ERDF
- European Union through the ERDF
- FCT
- [POCI-01-0145-FEDER-028736]
Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While there are several reviews highlighting the anticoagulant and antithrombotic activities of marine-derived sulfated polysaccharides, reports including other molecules are sparse. Therefore, the present paper provides an update of the recent progress in marine-derived sulfated polysaccharides and quotes other scaffolds that are being considered for investigation due to their antithrombotic effect.
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