期刊
MARINE DRUGS
卷 17, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/md17020079
关键词
PCSO-524((R)); neuroinflammation; neuronal cell cycle event; neuroprotection; Alzheimer's disease
资金
- State Key Laboratory of Molecular Neuroscience
- Research Grants Council
- HKSAR [AoE/M-604/16, HKUST 12/CRF/13G, GRF660813, GRF16101315]
- Hong Kong Ph.D. Fellowship Scheme
Cell cycle reentry is a unified mechanism shared by several neurodegenerative diseases, including Alzheimer's disease (AD) and Ataxia Telangiectasia (A-T). This phenotype is often related to neuroinflammation in the central nervous system. To mimic brain inflammation in vitro, we adopted the previously established method of using conditioned medium collected from activated THP-1 cells and applied it to both differentiated HT22 cells and primary neurons. Unscheduled cell cycle events were observed in both systems, indicating the potential of this approach as an in vitro model of neurodegenerative disease. We used this assay to measure the neuroprotective effects of New Zealand green-lipped mussel extract, PCSO-524((R)), to protect post-mitotic cells from cell cycle reentry. We found that, both in vitro and in an animal model, PCSO-524((R)) displayed promising neuroprotective effects, and thus has potential to postpone or prevent the onset of neurodegenerative disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据