期刊
MARINE DRUGS
卷 17, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/md17020077
关键词
Pseudallescheria boydii; indole alkaloid; pseudboindole; cytotoxic activity
资金
- National Natural Science Foundation of China [81872795]
- Guangdong Provincial Science and Technology Research Program [2016A020222004]
- Natural Science Foundation of Guangdong Province [2018A030313157]
- National Science and Technology Major Project for New Drug Innovation and Development [2017ZX09305010]
The composition of the culture medium has great influence on the metabolite production of the marine fungus Pseudallescheria boydii F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (1 and 2), together with 11 known indole alkaloids were isolated from the culture broth. Their structures were elucidated by comprehensive analysis of the NMR, MS, IR, and UV spectra. The 3,3-cyclohexylidenebis(1H-indole) (3) showed cytotoxic activity against various cancer cell lines.
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