期刊
MARINE DRUGS
卷 17, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/md17020100
关键词
Jaspis splendens; jasplakinolide Z(6); jasplakinolide Z(5); cytotoxic activity
资金
- Junior Scientist and International Research Center (JUNO) at Heinrich-Heine University (Dusseldorf, Germany)
- Manchot Foundation
A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC50 values in the low micromolar to nanomolar range.
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