期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 40, 期 10, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201800911
关键词
iron oxide nanoparticles; LCST behavior; magnetic resonance imaging; poly(2-oxazine)s; polymer brushes
资金
- Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
- German National Academic Foundation
- Elite Netzwerk Bayern (ENB)
- NHMRC-ARC Dementia Research Development Fellowship [APP1109945]
- ARC
- University of Warwick
- NIF Fellowships
- DAAD
Brush polymers are highly functional polymeric materials combining the properties of different polymer classes and have found numerous applications, for example, in nanomedicine. Here, the synthesis of functional phosphonate-ester-bearing brush polymers based on poly(2-oxazine)s is reported through a combination of cationic ring-opening polymerization (CROP) of 2-ethyl-2-oxazine and reversible addition-fragmentation chain transfer (RAFT) polymerization. In this way, a small library of well-defined (D <= 1.17) poly(oligo(2-ethyl-2-oxazine) methacrylate) P(OEtOzMA)(n) brushes with tunable lower critical solution temperature (LCST) behavior and negligible cell toxicity is prepared. Upon deprotection, the phosphonic acid end-group of the P(OEtOzMA)(n) brush enables the successful grafting-onto iron oxide nanoparticles (IONPs). Colloidal stability of the particle suspension in combination with suitable magnetic resonance imaging (MRI) relaxivities demonstrates the potential of these particles for future applications as negative MRI contrast agents.
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