期刊
MACROMOLECULAR BIOSCIENCE
卷 19, 期 5, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201800424
关键词
bacterial penetration; bi-layer hydrogels; gradually changing pore sizes; moisture retention ability; wound healing
资金
- National Natural Science Foundation of China [21874287, 21576222, 21476182, 21606179]
- Shaanxi Key Laboratory of Degradable Biomedical Materials Program [14JS103, 2016SZSj-35]
Wound dressings are vital for cutaneous wound healing. In this study, a bi-layer dressing composed of polyvinyl alcohol/carboxymethyl cellulose/polyethylene glycol (PVA/CMC/PEG) hydrogels is produced through a thawing-freezing method based on the study of the pore size of single-layer hydrogels. Then the physical properties and healing of full-thickness skin defects treated with hydrogels are inspected. The results show that the pore size of the single-layer PVA/CMC/PEG hyrogel can be controlled. The obtained non-adhesive bi-layer hydrogels show gradually increasing pore sizes from the upper to the lower layer and two layers are well bonded. In addition, bi-layer dressings with good mechanical properties can effectively prevent bacterial penetration and control the moisture loss of wounds to maintain a humid environment for wounds. A full-thickness skin defect test shows that bi-layer hydrogels can significantly accelerate wound closure. The experiment indicates that the bi-layer PVA/CMC/PEG hydrogels can be used as potential wound dressings.
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