期刊
MACROMOLECULAR BIOSCIENCE
卷 19, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201800365
关键词
intracellular distribution; nanocapsule; sonodynamic therapy; sonosensitizer
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [26107715]
- Joint Usage/Research Program on Zero-Emission Energy Research, Institute of Advanced Energy, Kyoto University [ZE30B-01]
- Grants-in-Aid for Scientific Research [26107715] Funding Source: KAKEN
Sonodynamic therapy (SDT) is a novel promising noninvasive therapy involving utilization of low-intensity ultrasound and sonosensitizer, which can generate reactive oxygen species (ROS) by sonication. In SDT, a high therapeutic effect is achieved by intracellular delivery and accumulation at the target sites of sonosensitizer followed by oxidative damage of produced ROS by sonication. Here, pH- and redox-responsive hollow nanocapsules are prepared through the introduction of disulfide cross-linkages to self-assembled polymer vesicles formed from polyamidoamine dendron-poly(l-lysine) for the efficient delivery of sonosensitizer. As sonosensitizer, doxorubicin (DOX), an anticancer drug accumulating into cell nucleus, is selected. Also, the conjugate of DOX and triphenylphosphonium (TPP-DOX) is synthesized as sonosensitizer with mitochondrial targeting ability. DOX and TPP-DOX are delivered to nucleus and mitochondria by nanocapsules. Furthermore, DOX- or TPP-DOX-loaded nanocapsules exhibit in vitro sonodynamic therapeutic effect to HeLa cells with sonication, which might be through oxidative damage to nucleus and mitochondria.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据