4.3 Article

DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin

期刊

LEUKEMIA & LYMPHOMA
卷 60, 期 6, 页码 1429-1437

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2018.1533128

关键词

Hodgkin lymphoma; AYA; survivors; twins; blood; saliva; DNA methylation

资金

  1. National Institutes of Environmental Health Science [1R01ESO15150-01]
  2. National Cancer Institute [1R03CA110836]
  3. Leukemia Lymphoma Society [TRP-6137-07]
  4. Department of Defense Peer-Reviewed Medical Research Program [PR054600]
  5. American Society of Hematology Bridge Grant Program

向作者/读者索取更多资源

DNA methylation (DNAm) silences gene expression and may play a role in immune dysregulation that is characteristic of adolescent/young adult Hodgkin lymphoma (AYAHL). We used the Infinium HumanMethylation27 BeadChip to quantify DNAm in blood (N=9 pairs, mean age 57.4 y) or saliva (N=36 pairs, mean age 50.0 y) from long-term AYAHL survivors and their unaffected co-twins. Epigenetic aging (DNAm age) was calculated using previously described methods and compared between survivors and co-twins using paired t-tests and analyses were stratified by sample type, histology, sex, age at sample collection and time since diagnosis. Differences in blood DNAm age were observed between survivors and unaffected co-twins (64.1 vs. 61.3 years, respectively, p=.04), especially in females (p=.01); no differences in saliva DNAm age were observed. Survivors and co-twins had 74 (in blood DNA) and 6 (in saliva DNA) differentially methylated loci. Our results suggest persistent epigenetic aging in AYAHL survivors long after HL cure.

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