期刊
ANALYTICA CHIMICA ACTA
卷 930, 期 -, 页码 1-12出版社
ELSEVIER
DOI: 10.1016/j.aca.2016.05.007
关键词
i-motif; Sensor; pH; Glucose; Silver (I) ions; Nanocontainers
资金
- National Science Center (NCN) of Poland [2015/17/B/ST4/03627]
Polycytosine DNA strands are often found among natural sequences, including the ends of telomeres, centromeres, and introns or in the regulatory regions of genes. A characteristic feature of oligonucleotides that are rich in cytosine (C-rich) is their ability to associate under acidic conditions to form a tetraplex i-motif consisting of two parallel stranded cytosine-hemiprotonated cytosine (C center dot C+) base-paired duplexes that are mutually intercalated in an antiparallel orientation. Nanotechnology has been exploiting the advantages of i-motif pH-dependent formation to fabricate nanomachines, nanoswitches, electrodes and intelligent nanosurfaces or nanomaterials. Although a few reviews regarding the structure, properties and applications of i-motifs have been published, this review focuses on recently developed biosensors (e.g., to detect pH, glucose or silver ions) and drug-delivery biomaterials. Furthermore, we have included examples of sensors based on parallel C-rich triplexes and silver nano-clusters (AgNCs) fabricated on cytosine-rich DNA strands. The potential diagnostic and therapeutic applications of this type of material are discussed. (C) 2016 Elsevier B.V. All rights reserved.
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