期刊
ANALYTICA CHIMICA ACTA
卷 940, 期 -, 页码 143-149出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2016.08.037
关键词
Slug-flow microextraction; Paper spray; Mass spectrometry; Macrolide antibiotics; Perfluorinated compounds
资金
- National Natural Science Foundation of China (NSFC) [21277177, 21307167, 41473092]
- Scientific and Technological Project of Guangdong Province [2013B031500003, 2014B070705001, 2016A040403057]
- South China Sea Branch of State Oceanic Administration
- Administration of Ocean and Fisheries of Guangdong Province
Analysis of trace compounds in small-volume complex samples is of importance for forensic, clinical, pharmaceutical, environmental, and life science investigation. In this study, we reported the coupling of slug-flow microextraction with paper spray mass spectrometry for rapid analysis of trace analytes in small volume of complicated biological samples such as whole blood, milk, and body fluid, etc. The method is performed by applying a disposable glass capillary for rapid extraction of a small amount of complex samples using a small amount of organic solvent; the loaded organic solvent was then spotted onto a paper triangle and dried out; subsequently, a high voltage and some spray solvent were applied onto the paper triangle for mass spectrometric analysis. By using the proposed method, high sensitivity and satisfactory precision for quantitative analysis of trace macrolide antibiotics in whole bloods and milks as well as perfluorinated compounds in individual small organisms have been successfully achieved. In addition, investigation of bioaccumulation of perfluorinated compounds in individual small organisms has been reached. (C) 2016 Elsevier B.V. All rights reserved.
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