期刊
LANCET NEUROLOGY
卷 18, 期 2, 页码 185-197出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(18)30460-5
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资金
- International Advisory Committee on Clinical Trials in Multiple Sclerosis
- US National Multiple Sclerosis Society
- European Committee for Treatment and Research in Multiple Sclerosis
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [ZIANS003119] Funding Source: NIH RePORTER
Spinal cord involvement is an important cause of disability in patients with multiple sclerosis or neuromyelitis optica spectrum disorders (NMOSDs). Multiple sclerosis and NMOSDs can be distinguished from other disorders that cause myelopathy by results from laboratory and radiological investigations. However, limitations in the sensitivity and specificity of spinal cord imaging and poor correlation with disability megasures have impeded the understanding of the relationship between spinal cord involvement and clinical manifestations. Nevertheless, studies of the pathological features of multiple sclerosis and NMOSDs have shown that quantitatively different mechanisms lead to differences in clinical course and pattern of accrual of permanent disability in the two dis-orders. Better understanding of these mechanisms is necessary to develop more informative clinical measures, electrophysiological methods, fluid biomarkers, and imaging techniques to detect and monitor spinal cord involvement in the diagnosis and management of patients with multiple sclerosis or NMOSDs, and as outcome measures in clinical trials.
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