期刊
ANALYTICA CHIMICA ACTA
卷 913, 期 -, 页码 137-144出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2016.01.063
关键词
Carboxyl-functionalized graphene oxide; Gold nanostars; Surface plasmon resonance (SPR) biosensor; Pig IgG
资金
- Special-funded Programme on National Key Scientific Instruments and Equipment Development of China [2012YQ090194]
- National Natural Science Foundation of China [21207047, 21405057]
- Science and Technology Developing Foundation of Jilin Province [20150311099YY, 20121808, 20150204017YY]
A new high-sensitivity surface plasmon resonance (SPR) biosensor based on biofunctional gold nanostars (AuNSs) and carboxyl-functionalized graphene oxide (cGO) sheets was described. Compared with spherical gold nanoparticles (AuNPs), the anisotropic structure of AuNSs, which concentrates the electric charge density on its sharp tips, could enhance the local electromagnetic field and the electronic coupling effect significantly. cGO was obtained by a diazonium reaction of graphene oxide (GO) with 4-aminobenzoic acid. Compared with GO, cGO could immobilize more antibodies due to the abundant carboxylic groups on its surface. Testing results show that there are fairly large improvements in the analytical performance of the SPR biosensor using cGO/AuNSs-antigen conjugate, and the detection limit of the proposed biosensor is 0.0375 mu g mL(-1), which is 32 times lower than that of graphene oxide-based biosensor. (C) 2016 Elsevier B.V. All rights reserved.
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