期刊
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
卷 99, 期 8, 页码 3967-3975出版社
WILEY
DOI: 10.1002/jsfa.9622
关键词
Cyclocarya paliurus flavonoids; intestinal microbiome; metagenomics; modulatory effect; obesity
资金
- Zhejiang Provincial Natural Science Foundation of China [LY19C200006]
- Key Research and Development Project of Zhejiang Province [2017C02039, 2018C02047]
- K. C. Wong Magna Fund of Ningbo University
BACKGROUND As a result of a low bioavailability, the majority of Cyclocarya paliurus flavonoids (CPF) remain in the large intestine where they accumulate to exert a modulatory effect on the intestinal micro-ecology. Therefore, the present study investigated the modulatory effect of CPF on intestinal microbiota. RESULTS CPF dramatically ameliorated the obesity-induced gut dysbiosis. A significant decrease (P < 0.05) was observed in the ratio of Firmicutes/Bacteroidetes after CPF treatment for 8 weeks. Moreover, Kyoto Encyclopedia of Genes and Genomes pathways of biosynthesis of amino acids, the two-component system and ATP-binding cassette transporters enriched the most differentially expressed genes after CPF intervention. CONCLUSION The results of the present study indicate that CPF might have prebiotic-like activity and could be used as a functional food component with potential therapeutic utility to prevent obesity-related metabolic disorders by manipulating the gut flora and affecting certain metabolic pathways, thus contributing to the improvement of human health. (c) 2019 Society of Chemical Industry
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