Straightforward multicomponent synthesis of pyrano[2,3-d]pyrimidine-2,4,7-triones in -cyclodextrin cavity and evaluation of their anticancer activity

In the present study, we have developed an efficient and green method for the synthesis of pyrano[2,3-d]pyrimidine-2,4,7-triones employing -cyclodextrin as a catalyst in aqueous media from substituted aldehydes, barbituric acid and meldrum acid. The reactions were performed under mild conditions to afford biologically active target molecules in excellent yields. All the synthesized compounds are evaluated for their in vitro anticancer activity against HePG-2 (Human liver cancer cell line) and MCF-7 (Human breast cancer cell line). Among them 4c, 4j, 4k, 4l and 4m were active and potent anticancer agents. [GRAPHICS] .