期刊
ANALYST
卷 141, 期 13, 页码 4001-4005出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6an00804f
关键词
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资金
- European Union
- province of Gelderland through the EFRO Ultrasense NMR project
- province of Overijssel through the EFRO Ultrasense NMR project
NMR spectroscopy is one of the most powerful techniques to simultaneously obtain qualitative and quantitative information in chemical analysis. Despite its versatility, the applications of NMR in the study of biofluids are often limited by the insensitivity of the technique, further aggravated by the poor signal dispersion in the 1H spectra. Recent advances in para-H-2 induced hyperpolarization have proven to address both these limitations for specific classes of compounds. Herein, this approach is for the first time applied for quantitative determination in biofluid extracts. We demonstrate that a combination of solid phase extraction, para-hydrogen induced hyperpolarization and selective NMR detection quickly reveals a doping substance, nikethamide, at sub-mu M concentrations in urine. We suggest that this method can be further optimized for the detection of different analytes in various biofluids, anticipating a wider application of hyperpolarized NMR in metabolomics and pharmacokinetics studies in the near future.
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