期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 9, 页码 3735-3754出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b11005
关键词
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资金
- National Institutes of Health [AI072155]
- National Science Foundation [CHE-1664283]
- Academia Sinica
- Kwang Hua Foundation
The translation of biological glycosylation in humans to the clinical applications involves systematic studies using homogeneous samples of oligosaccharides and glycoconjugates, which could be accessed by chemical, enzymatic or other biological methods. However, the structural complexity and wide-range variations of glycans and their conjugates represent a major challenge in the synthesis of this class of biomolecules. To help navigate within many methods of oligosaccharide synthesis, this Perspective offers a critical assessment of the most promising synthetic strategies with an eye on the therapeutically relevant targets.
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