期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 6, 页码 2274-2278出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b00396
关键词
-
资金
- D.J. & J.M. Cram Endowment
- NIH [RO1CA184772]
- NSF [CHE-1048804]
- UCLA NIH CBI training grant [T32GM008496]
An eight-step asymmetric synthesis of (+)-marineosin A is described. The route proceeds by condensing fragments of reversed polarity relative to conventional prodiginine constructions. The resultant unstable chromophore is disrupted by a unique cycloisomerization promoted at a tailored manganese surface. This provides a premarineosin and subsequently marineosin A in a particularly concise manner. A pyridinophane N-oxide photorearrangement in flow and structural isomers of premarineosin are discussed, as is the reassignment of marineosin stereochemistry. The route gives access to the natural product as well as diastereomers, congeners and analogs that are currently inaccessible by other means.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据