期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 8, 页码 3440-3443出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b00621
关键词
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资金
- National Young 1000 Talents Plan Program, College of Chemistry and Molecular Engineering, Peking University
- Peking-Tsinghua Center for Life Sciences
- National Science Foundation of China [21472003, 31521004, 21673011, 21822101]
- Ministry of Science and Technology [2017YFA0104000]
- High-performance Computing Platform of Peking University
Vinigrol is a structurally and stereochemically complex natural product that displays various potent pharmacological activities, including the capability to modulate TNF-alpha. A new and efficient synthetic route toward this natural product has been developed to complete the asymmetric synthesis of (-)-vinigrol and provide over 600 mg of material, manifesting the power of macrocyclic stereocontrol and transannular Diels-Alder reaction.
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