期刊
JOURNAL OF SEPARATION SCIENCE
卷 42, 期 10, 页码 1948-1954出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201900071
关键词
cyclodextrins; enantiomers; gold nanoparticles; open-tubular capillary electrochromatography; sol-gel processing
资金
- National Natural Science Foundation of China [81473178]
A novel open-tubular capillary electrochromatography column coated with beta-cyclodextrin was prepared using the sol-gel technique. In the sol-gel approach, owing to the three-dimensional network of sol-gel and the strong chemical bond between the stationary phase and the surface of capillary columns, good chromatographic characteristics and unique selectivity in separating enantiomers were shown. The influences of capillary inner diameter, coating time, organic modifier, buffer pH, and buffer concentration on separation were investigated. The sol-gel-coated beta-cyclodextrin column has shown improved enantioseparation efficiency of chlorphenamine, brompheniramine, pheniramine, zopiclone in comparison with the sol-gel matrix capillary column. The migration time relative standard deviation of the separation of the enantiomers was less than 0.89% over five runs and 2.9% from column to column. This work confirmed that gold nanoparticles are promising electrochromatographic support to enhance the phase ratio of open-tubular capillary electrochromatography column in capillary electrochromatography.
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