期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 113, 期 -, 页码 117-124出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2019.03.012
关键词
Severe mental illness; Thinking skills for work; Cognition; Cognitive remediation; Neuropsychological functioning
类别
资金
- National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) [90AR5018]
- NIDILRR [H133G050230, H133G090206]
- NIDILRR/SAMHSA [9ORT5029]
- NIMH [R01 MH077210]
- New York State Office of Mental Health
- Center for Rehabilitation and Recovery, Coalition of Behavioral Health Agencies Incorporated, New York
Cognitive remediation is aimed at reducing cognitive impairments in severe mental illnesses such as schizophrenia, but little is known about whether severity of cognitive impairment predicts benefit from this intervention. To address this question, this study aggregated data from five randomized controlled trials (N = 300) of a standardized comprehensive, multimodal outpatient cognitive remediation program, the Thinking Skills for Work program, and evaluated whether baseline level of cognitive impairment differentially predicted improvement in cognitive functioning following cognitive remediation vs. usual services. Using standardized scores of neuropsychological functioning to designate low average, moderate, and severe levels of cognitive impairment, participants with greater cognitive impairment were found to benefit differentially more from cognitive remediation than usual services compared to less cognitively impaired participants. The findings were unaffected by statistically controlling for participant demographic and clinical characteristics. The findings suggest that individuals with the greatest cognitive impairment, for whom cognitive remediation was developed, are also most likely to benefit from this intervention.
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