期刊
JOURNAL OF PROTEOME RESEARCH
卷 18, 期 3, 页码 1208-1217出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jproteome.8b00811
关键词
systemic lupus erythematosus; cytokine; multivariate data analysis; subgrouping; HCA; OPLS-DA
资金
- AstraZeneca-Karolinska Institutet Joint Research Program in Translational Science
- Swedish Research Council [2017-02577, 2014-33867]
- VINNOVA
- Swedish Heart-Lung Foundation
- Stockholm County Council (ALF) [20160378, 20170038]
- King Gustaf V 80th Birthday Fund
- Swedish Rheumatism Association [R-755861, R-73931]
- Karolinska Institutet's Foundations
- Foundation in memory of Clas Groschinsky
- Swedish Society of Medicine
- Ingegerd Johanssons foundation
- Innovative Medicines Initiative (EU/EFPIA, ULTRA-DD Grant) [115766]
- Swedish Research Council [2017-02577] Funding Source: Swedish Research Council
The aim of this study was to evaluate how the cytokine profiles differed between autoantibody based subgroups of systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disease, characterized by periods of flares (active disease) and remission (inactive disease). The disease can affect many organ systems, e.g., skin, joints, kidneys, heart, and the central nervous system (CNS). SLE patients often have an overproduction of cytokines, e.g., interferons, chemokines, and interleukins. The high cytokine levels are part of the systemic inflammation, which can lead to tissue injury. In the present study, SLE patients were divided into five groups based on their autoantibody profiles. We thus defined these five groups: ANA negative, antiphospholipid (aPL) positive, anti-Sm/anti-RNP positive, Sjogren's syndrome (SS) antigen A and B positive, and patients positive for more than one type of autoantibodies (other SLE). Cytokines were measured using Mesoscale Discovery (MSD) multiplex analysis. On the basis of the cytokine data, ANA negative patients were the most deviating subgroup, with lower levels of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-12/IL-23p40, and interferon gamma-induced protein (IP)-10. Despite low cytokine levels in the ANA negative group, autoantibody profiles did not discriminate between different cytokine patterns.
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