Syntheses, structures and in vitro cytostatic activity of four novel homochiral organotin(IV) phosphonates

Four novel homochiral organotin phosphonates, namely, (R)-, (S)-[(Me3Sn)(2)(pemp)(H2O)](n) (1, 2) and (R) -, (S)-[(Ph3Sn)(2)(pemp)(2)](n) (3, 4) [pempH(2) = (R)-or (S)-(1-phenylethylamino) methylphosphonic acid], were synthesized and characterized by X-ray diffraction analysis, elemental analysis, FT-IR, NMR (H-1, C-13, P-31 and Sn-119), TGA (thermogravimetric analysis) and CD (circular dichroism spectra). The structure analysis indicates that complex 1 displays 1D left-handed helical chain and complex 2 shows right-handed helical chain. These 1D chains are further linked into a 2D supramolecular network architecture through the intermolecular O-H center dot center dot center dot O interactions. Complexes 3 and 4 are isostructural that showing 1D infinite zig-zag chain structure. In addition, the molecules of complexes 3 and 4 are further linked through intermolecular C-H center dot center dot center dot pi interactions into a 2D supramolecular structure. Furthermore, we preliminarily estimated in vitro cytostatic activity of complexes 1-4 against the human cervix tumor cells (HeLa) and the human hepatocellular carcinoma cells (HepG-2). (c) 2018 Elsevier B.V. All rights reserved.