期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 7, 页码 3887-3903出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b03015
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资金
- Swedish Research Council [2014-04673, 2018-04589]
- Knut and Alice Wallenberg foundation [KAW 2013.0031]
- Goran Gustafsson foundation
- Kempe Foundation [SMK-1755]
- Swedish Foundation for Strategic Research [SB12-0070]
- Michael J Fox foundation
- Swedish Research Council [2018-04589, 2014-04673] Funding Source: Swedish Research Council
- Swedish Foundation for Strategic Research (SSF) [SB12-0070] Funding Source: Swedish Foundation for Strategic Research (SSF)
We here describe the use of three-component reactions to synthesize tricyclic pyridine ring-fused 2-pyridones. The developed protocols have a wide substrate scope and allow for the installation of diverse chemical functionalities on the tricyclic central fragment. Several of these pyridine-fused rigid polyheterocycles are shown to bind to Afi and a-synuclein fibrils, which are associated with neurodegenerative diseases.
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