期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 6, 页码 3370-3376出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b03222
关键词
-
资金
- Defense Advanced Research Projects Agency (DARPA) [W911NF-16-2-0023]
Ciprofloxacin is a broad-spectrum antibiotic that is recognized as one of the World Health Organization's Essential Medicines. It is particularly effective in the treatment of Gram-negative bacterial infections associated with urinary, respiratory, and gastrointestinal tract infections. A streamlined and high yielding continuous synthesis of ciprofloxacin has been developed, which employs a chemoselective C-acylation step that precludes the need for intermediate isolations, extractions, or purifications. The end-to-end process has a residence time of 4.7 min with a 15.8 g/h throughput at laboratory scale and an overall isolated yield of 83%.
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