期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 68, 期 -, 页码 51-58出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2019.03.004
关键词
Adipocytes; LDL; Diet; Lipid mediators; Dietary lipids; Lipoprotein metabolism
资金
- California Walnut Commission
- United States Department of Agriculture [2032-51, 530-022-00D]
- National Institutes of Health [U24 DK097154-01]
Walnut consumption can provide both vascular and metabolic health benefits, and walnut-induced changes in lipoprotein particle chemical payloads may be responsible for these health benefits. To explore this possibility with a focus on metabolic health, this study investigated the impact of walnut consumption on lipoprotein lipid composition and changes in LDL anti-inflammatory properties, as reported by inflamed adipocyte. Hypercholesterolemic, postmenopausal females were treated with 40 g/day (i.e., 1.6 servings/day; n=15) of walnuts for 4 weeks. Fatty acids and their oxygenated metabolites, i.e., oxylipins, were quantified in isolated lipoproteins. Human primary adipocytes were exposed to LDL and TNF alpha-stimulated adipokine production was measured. Walnut treatment elevated alpha-linolenic acid and its epoxides in all lipoproteins and depleted mid-chain alcohols in VLDL and LDL, but not HDL. Walnuts also reduced TNF alpha-induced diabetic adipocyte production of IL-6 (-48%, P=.0006) and IL-8 (-30%, P=.01), changes inversely correlated with levels of alpha-linolenic acid derived epoxides but not alpha-linolenic acid itself. In conclusion, modest walnut consumption can alter lipoprotein lipid profiles and enhance their ability to inhibit TNF alpha-dependent pro-inflammatory responses in human diabetic primary adipocytes. Moreover, this study suggests the oxylipins, rather than the parent fatty acids, mediate LDL action of adipocytes. (C) 2019 Elsevier Inc. All rights reserved.
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