期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 64, 期 -, 页码 61-71出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2018.10.006
关键词
Sesamin; Chronic unpredictable mild stress; Cognition; Depression; Neuroinflammation
资金
- National Key Research and Development Program of China [2016YFD0400601]
- National Natural Science Foundation of China [81803231]
- Key Research and Development Plan of Shaanxi, China [2018NY-100]
- China postdoctoral science foundation [2018 T111104]
- Fundamental research funds for the central universities [2452017141]
Depression is a mood disorder that is related to neuroinflammation and cognition loss. This study is aimed to determine the potential antidepressant effects of (+)-sesamin, a lignan component of sesame, in a mild stress-induced depression mouse model. CD-1 mice were treated with chronic unpredictable mild stress (CUMS) process and orally administrated with sesamin (50 mg/kg/d) for 6 weeks. Behavioral tests including forced swimming test, tail suspension test, open field test, and elevated plus maze test demonstrated that sesamin treatment inhibited CUMS-induced mice depressant-like behaviors and anxiety, without changing immobility. It was found that sesamin prevented stress-induced decease levels of 5-HT and NE in striatum and serum. Cognitive deficits were assessed using Y-maze and Morris water maze test. Sesamin treatment also prevented stressed-induced memory impairments and neuronal damages. Consistently, sesamin also enhanced synapse ultrastructure and improved expressions of PSD-95 in stressed mice hippocampus with improving neurotrophic factors expression including BDNF and NT3. Moreover, sesamin treatment significantly prevented CUMS-induced neuroinflammation by inhibiting over-activation of microglia and expressions of inflammatory mediators including iNOS, COX-2, TNF-alpha and IL-1 beta in stressed mice hippocampus and cortex. These results illustrated that sesamin markedly improved CUMS-induced depression and memory loss via inhibiting neuroinflammation, which indicate that as food component, sesamin might be also a novel potential therapeutic for depression. (C) 2018 Elsevier Inc. All rights reserved.
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