期刊
JOURNAL OF NUTRITION HEALTH & AGING
卷 23, 期 4, 页码 386-392出版社
SPRINGER FRANCE
DOI: 10.1007/s12603-019-1175-0
关键词
Vitality; elderly; activities of daily living; frailty; cognition
资金
- French Ministry of Health
- University Hospital Center of Toulouse / Gerontopole
- Pierre Fabre Research Institute
- University Hospital Center of Toulouse
- Association Monegasque pour la Recherche sur la maladie d'Alzheimer (AMPA)
- Exhonit Therapeutics
- Avid Radiopharmaceuticals
- UMR 1027 Unit INSERM-University of Toulouse III
ObjectivesThis study aimed to examine the associations of three operational definitions of vitality with variation in instrumental activities of daily living (IADL) and frailty over a 3-year follow-up among non-demented, community-dwelling elderly.DesignObservational study.Setting and participants1,679 elderly >70y (64.7% female) participants of the Multidomain Alzheimer Preventive Trial (MAPT).MeasurementsVitality was defined as a psychological concept using three items from the Geriatric Depression Scale; as a physical construct using the highest quartile for hand grip strength; and as global physiological reservoir using a combination of good physical and cognitive functions. Variables were assessed at baseline, 6, 12, 24 and 36 months of follow-up.ResultsPrevalence of high vitality at baseline was 57.1%, 28.5% and 21.6% for psychological, physical, and physiological reservoir, respectively. People with high vitality presented higher IADL scores compared to people with low vitality for all definitions. Analysis from the mixed-effect model found no differences between vitality groups for IADL performance across all definitions. IADL scores improved among subjects with high vitality over time, independent on the definition; while no significant variation was observed among those with low vitality. Participants with low vitality presented 2.0 to 6.1 higher odds of having more frailty components over time (p<0.0001).ConclusionHigh vitality defined as a concept related to psychological, physical, or physiological reservoir constructs were positively associated with better IADL performance and with reduced likelihood of frailty worsening over time.
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