期刊
JOURNAL OF NEUROSCIENCE
卷 39, 期 19, 页码 3627-3639出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2060-18.2019
关键词
Default Mode Network; function; morphology; sulcus; vmPFC
资金
- 16 institutes of the National Institutes of Health (NIH) and Centers [1U54MH091657]
- McDonnell Center for Systems Neuroscience at Washington University
- Fondation pour la Recherche Medicale
- Sir Henry Dale Wellcome Trust Fellowship [105651/Z/14/Z]
- Wellcome Trust [203139/Z/16/Z]
The ventromedial prefrontal cortex (vmPFC), which comprises several distinct cytoarchitectonic areas, is a key brain region supporting decision-making processes, and it has been shown to be one of the main hubs of the DefaultModeNetwork, a network classically activated during resting state. We here examined the interindividual variability in the vmPFC sulcal morphology in 57 humans (37 females) and demonstrated that the presence/absence of the inferior rostral sulcus and the subgenual intralimbic sulcus influences significantly the sulcal organization of this region. Furthermore, the sulcal organization influences the location of the vmPFC peak of the Default Mode Network, demonstrating that the location of functional activity can be affected by local sulcal patterns. These results are critical for the investigation of the function of the vmPFC and show that taking into account the sulcal variability might be essential to guide the interpretation of neuroimaging studies.
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