期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 4, 页码 1034-1039出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00988
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资金
- National Research Foundation (NRF) grant of the Korean government (MSIP) [NRF-2017R1D1A1B03032939, NRF-201.5M1A5A-1041808]
Herein, we clarify the structure and relative configurations of two prorocentrolide analogues (1 and 2) isolated from the benthic marine dinoflagellate Prorocentrum lima. The results of NMR spectroscopy show that 1 is prorocentrolide substituted by a hydroxy group at C-4, while the newly isolated compound 2 can be thought of as 1 lacking one ether ring and having one extra double bond. The relative configurations of all stereogenic centers and the configurations of the double bonds in 1 and 2 were determined utilizing ROESY correlations and J-based configuration analysis. Furthermore, 2 was shown to exhibit cytotoxicity against HCT-116 and Neuro-2a cells (IC50 2.2 and 5.2 mu M, respectively.
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