期刊
JOURNAL OF MOLECULAR MEDICINE-JMM
卷 97, 期 4, 页码 473-485出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-018-01738-w
关键词
MOTS-c; Ovariectomy; Metabolic disorder; Adipose; AMPK
资金
- National Natural Science Foundation of China [NSF: 31571215, NSF: 31270843, NSF: 81330045, NSF: 81730053]
- Military Logistics Research Project [AWS14L008, AWS16J022]
The postmenopausal state is associated with an increased risk of metabolic disorder including reduced energy expenditure and weight gain, leading to higher cardiovascular and cancer risks among other diseases. Mitochondrial-derived peptide (MOTS-c) is a 16-amino acid peptide encoded by mitochondrial DNA. Here, we showed that MOTS-c treatment in mice prevented ovariectomy-induced obesity and insulin resistance. After ovariectomy, low levels of estrogens increased fat mass overload and disturbed normal adipose function, forcing the development of insulin resistance. MOTS-c treatment increased brown fat activation and reduced OVX-induced fat accumulation and inflammatory invasion in white adipose tissue, which contributes to the lower level of fatty acid in serum and liver. Moreover, MOTS-c activated AMPK pathway to improve energy dissipation and insulin sensitivity. And a blocker of AMPK pathway was found to attenuate the role of MOTS-c in the regulation of adipocyte lipid metabolism. In conclusion, MOTS-c is a high potential candidate for chronic treatment of menopausal induced metabolic dysfunction.Key messages center dot MOTS-c prevents ovariectomy (OVX)-induced body weight gain and insulin resistance.center dot MOTS-c reduces fat mass and suppresses inflammatory response under OVX condition.center dot MOTS-c sustains the activity of the brown adipose under OVX condition.center dot MOTS-c mediates AMPK pathway activation to control adipose metabolic homeostasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据