C-O bond formation via oxidative-coupling pathway in eutectic mixture of choline chloride/urea as a green solvent

C-O bond formation between terminal alkenes/benzyl alcohols as an arylcarboxy surrogate and carbonyl compounds in a biodegradable deep eutectic solvent (DES) based on choline chloride and urea was performed. By employment of TBAI as catalyst and TBHP as oxidant, various derivatives of carbonyl compounds were benzylated in alpha position in good to high yield at 90 degrees C. Moreover, alpha-oxybenzoylation of diethyl malonate with carboxylic acids was performed in the above-mentioned DES by employment of NaI as the catalyst and TBHP as the oxidant at 60 degrees C. (C) 2018 Elsevier B.V. All rights reserved.