期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 431, 期 20, 页码 4078-4092出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2019.02.008
关键词
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资金
- Wellcome Trust
- Medical Research Council (MRC)
- Biotechnology and Biological Sciences Research Council (BBSRC)
- BBSRC David Phillips Fellowship
- Wellcome Trust Investigator Award
- BBSRC [BB/E023703/1] Funding Source: UKRI
- MRC [MR/P028225/1, MC_PC_16046, MC_PC_17162] Funding Source: UKRI
The parasitic life cycle of viruses involves the obligatory subversion of the host's macromolecular processes for efficient viral progeny production. Viruses that infect bacteria, bacteriophages (phages), are no exception and have evolved sophisticated ways to control essential biosynthetic machineries of their bacterial prey to benefit phage development. The xenogeneic regulation of bacterial cell function is a poorly understood area of bacteriology. The activity of the bacterial transcription machinery, the RNA polymerase (RNAP), is often regulated by a variety of mechanisms involving small phage-encoded proteins. In this review, we provide a brief overview of known phage proteins that interact with the bacterial RNAP and compare how two prototypical phages of Escherichia coli, T4 and T7, use small proteins to puppeteer the bacterial RNAP to ensure a successful infection. (C) 2019 The Authors. Published by Elsevier Ltd.
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