期刊
JOURNAL OF MEMBRANE SCIENCE
卷 581, 期 -, 页码 373-382出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.memsci.2019.03.082
关键词
Polyethersulfone membranes; Anti-fouling property; Hemocompatibility; In-situ ring-opening reaction; Hemodialysis
资金
- National Natural Science Foundation of China [51433007, 51673125, 51773127, 51803131, 51803134, 51873115]
- State Key Research Development Programme of China [2016YFC1103000, 2018YFC1106400]
- Science and Technology Program of Sichuan Province [2017SZ0011, 2019YJ0132]
Although many methods have been investigated to enhance the anti-fouling and hemocompatility of polymeric membranes, developing simplified and high-efficiency strategies to synthesize low-fouling and hemocompatible membranes for safe blood purification remains a huge challenge. Herein, we proposed a facile and straightforward approach to solve the aforementioned problems. Firstly, poly (glycidyl methacrylate) (PGMA) was incorporated into polyethersulfone (PES) membranes via a combination of an in-situ crosslinking polymerization and the phase inversion method. Then, poly (acrylic acid-co-2-acrylanmido-2- methylpropanesulfonic acid) (PAA-AMPS) was covalently coated onto the PES membrane surfaces via an in-situ ring-opening reaction between the PAA and PGMA by simply immersing the membranes into the PAA-AMPS solution. Compared to pristine PES membrane, the protein adsorption amount of the modified membranes reduced; the flux recovery ratio and the resistance to blood cell and bacteria adhesion significantly increased. In addition, the hemo-compatibility of the modified membranes was significantly improved, as indicated by the prolongation of the activated partial thromboplastin time and thrombin time of PES-based membranes by 157% and 584% respectively. The proposed simple and high-efficient strategy in this study might be a powerful tool to fabricate polymeric membranes with various and desired functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据